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Regarding macrophage infiltration, Ibrahim et al

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

The GCL enzyme is a heterodimer formed by two subunits: the heavy subunit or glutamate cysteine ligase catalytic subunit (GCLC, 73 kDa) and the light subunit or glutamate cysteine ligase modulating subunit (GCLM, 30 kDa)